Naked Replication Forks Break apRPArt
نویسندگان
چکیده
Stalled replication forks occasionally collapse, leading to potentially catastrophic DNA double-strand breaks. Now, Toledo et al. (2013) reveal that fork breakage occurs when the pool of the single-strand DNA-binding protein RPA becomes exhausted. This study has important implications for the origin and treatment of cancers with high levels of replicative stress.
منابع مشابه
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عنوان ژورنال:
- Cell
دوره 155 شماره
صفحات -
تاریخ انتشار 2013